The topics presented here include mechanism of action of anti-inflammatory drugs, enzymes involved in arachidonic acid metabolism, their cloning and crystal...
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Livré chez vous entre le 28 août et le 3 septembre
En magasin
Résumé
The topics presented here include mechanism of action of anti-inflammatory drugs, enzymes involved in arachidonic acid metabolism, their cloning and crystal structure, the effect of inhibitors and cell knockout, novel receptors and their mechanism of signal transduction, anti-inflammatory eicosanoids and eicosanoid regulation of inflammation and metastasis. Understanding the cellular and molecular basis of the inflammatory response continues to evolve with the discovery of new pathways and mediators. The quest for new anti-inflammatory agents depends on the elucidation of biochemical pathways involved in the initiation and termination of the inflammatory response. The topics presented here are state of the art and provide insights into novel approaches.
Sommaire
The Mechanism of Action of anti-inflammatory Drugs
Human Group-V Phospholipase-A² Expression in Pichia pastoris and Its Role in Eicosanoid Generation
Fatty-Acid Substrate Interactions with Cyclooxygenases
Structure, Function and Inhibition of Cyclooxygenases
Leukotriene-A4 Hydrolase: Probing the Active Sites and Catalytic Mechanisms by Site-Directed Mutagenesis
The Regulation of Cyclooxygenase-1 and -2 in Knockout Cells and Cyclooxygenase and Fever in Knockout Mice
Leudotriene-B4 Receptor and Signal Transduction
Lipoxins, Aspirin-Triggered 15-epi-Lipoxin Stable Analogs and Their Receptors in Anti-inflammation: a Window for Therapeutic Opportunity
Lipoxin-Stable Analogs: Potential Therapeutic Downregulators of Intestinal Inflammation
The Role of Eicosanoids in Tumor Growth and Metastasis.