Brain Targeted Drug Delivery Systems - A Focus on Nanotechnology and Nanoparticulates - Grand Format

Brain Targeted Drug Delivery Systems reviews current developments in brain-targeted_drug delivery with a focus on nanotechnology and nanoparticulates. The brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life. Brain targeting drug delivery systems are one solution to improving the treatment of CNS disorders, but due to the blood brain barrier (BBB), it is difficult to deliver drugs directly to the brain.
This book explores the complex discussions surrounding the research area with a focus on how to deliver drugs to the brain, why it is important, current developments in the area, and the unmet concerns with the current research into brain-targeted drug delivery. Following an introduction, initial chapters discuss the anatomy and physiology of the BBB, recent progress in BBB transportation research and models ; receptor, carrier and absorptive mediated transcytosis transportation methods and the efflux pump inhibition to enhance brain targeting delivery.
Later chapters focus on intranasal drug delivery, brain local delivery strategy, glioma, neurodegenerative diseases and ischemia targeted delivery systems, neurotoxicityconcerns, intra-brain distribution and the elimination of brain-targeted nanomaterials. Brain Targeted Drug Delivery Systems provides expert discussion and key analysis on the development of brain-targeted drug delivery. This book summarizes available strategies, and considers the main issues and pitfalls evidenced in current studies on this complex subject.
It is an essential guide to pharmaceutical industry scientists, academic researchers, and graduate students of pharmaceutical, science ; materials scientists working in drug delivery and nanotechnology, clinical researchers (including neuroscientists), and cancer researchers.