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Since its initial publication in 1982, Cancer Epidemiology and Prevention has served as the premier reference work for students and professionals working to understand the causes and prevention of cancer in humans. Now revised for the first time in more than a decade, this fourth edition provides a comprehensive summary of the global patterns of cancer incidence and mortality, current understanding of the major causal determinants, and ationale for preventive interventions.
Special attention is paid to molecular epidemiologic approaches that address the wider role of generic predisposition and gene-environment interactions in cancer etiology and pathogenesis. New and newly revised chapters reflect the last decade's dynamic shifts in the subject matter : Advances in genetic and molecular research on tumor biology Development of high-throughput laboratory technologies that allow "agnostic" (hypothesis-free) exploration of the the genome, epigenome, and transcriptome.
Identification of germline susceptibility loci associated with cancer risk. Identification of driver mutations in tumor tissue that provide the equivalent of a "molecular autopsy" of what went wrong. Progress in harnessing new insights and technologies into large-scale epidemiologic studies Major progress in cancer prevention in arm of tobacco control, vaccination against hepatitis B and HPV, and screening for colorectal cancer.
The rise of consortia, data pooling and new types of research (survivorship, intervention studies). For both seasoned professionals and newer generations of students and researchers, this fourth edition of Cancer Epidemiology and Prevention remains the authority in the field - a work of distinction that every lab, library, student, professional, or researcher should have dose at hand.