Ebola and Marburg viruses cause severe hemorrhagic fevers. Much research has been performed in recent years on the molecular and genetic properties of...
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Ebola and Marburg viruses cause severe hemorrhagic fevers. Much research has been performed in recent years on the molecular and genetic properties of these viruses and in particular has focused on molecular structure, replication and virus-host interactions. This book presents a comprehensive review of the current research on these highly virulent viruses. Topics covered include the genomics and molecular biology of filoviruses, pathogenesis, replication, epidemiology, pathogenicity, approaches to vaccine development, virus-host interactions and the immune response.
Sommaire
Genome Organization, Replication and Transcription of Filoviruses
Structure of Viral Proteins
Structural and Functional Polymorphism of the Glycoproteins of Filovirusers
Molecular Mechanisms of Filovirus Entry
Roles of Filoviral Matrix-and Glycoproteins in the Viral Life Cycle
Virus Maturation
Filovirus Pathogenesis in Nonhuman Primates
Ebola Virus Infection in the Guinea Pig
Pathogenesis of Filovirus Infection in Mice
The Role of Endothelial Cells in Filovirus Hemorrhagic Fever
Modulation of Innate Immunity by Filoviruses
Cellular and Molecular Mechanisms of Ebola Pathogenicity and Approaches to Vaccine Development.